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In this course, you will learn :
- Introduction to the Toxicology 21st century (Tox21c) field and familiarise you with the major paper, which summarise the main ideas and principles of Tox21c.
- Discuss the practical applications of ToxCast and Tox21 technology. The US EPA Endocrine Disruptor Screening Programme will be described in detail, and we will show how the ToxCast platform replaced in vivo tiered techniques in EDSP, hence speeding up the process of. The construction of in silico models for toxicity testing will be explored in the second lesson of this module.
- familiarise you with the Human Toxome Project, which is led by Johns Hopkins University in partnership with a number of universities, industries, and research organisations.
- Explain what read-across is, why it is necessary for regulatory risk assessment, and how industry might use it in response to REACH law.
- The organotypic cultures lesson will introduce you to existing in vitro cell-based models, beginning with simple monolayer cultures of cell lines and progressing to complicated integrated organ-on-a-chip and human-on-a-chip techniques.
- teach you about the importance of microRNA and epigenetics in toxicology and environmental health.
- Learn about in vitro toxicology components such as in vitro to in vivo extrapolation (IVIVE) and physiologically based biokinetic modelling.
- Learn why biokinetics in vitro is important and explore some examples of biokinetics modelling in vitro.
- You will also be given a biometry perspective of in vitro toxicity. You will discover which methods may be utilised to analyse large amounts of data.
- Discover how integrated testing strategies differ from individual tests or test batteries. A "beyond chemical" wrap-up session will summarise your understanding from this course and provide an outlook for future directions in the field of alternatives to animal testing.
