Welcome to the course on Evidence-based Toxicology (EBT). Evidence-based medicine has transformed the way information is evaluated in medicine and healthcare by making it transparent and objective. Over the last ten years, an effort has been made in North America and Europe to apply this revolution to the discipline of toxicology.
The Centre for Alternatives to Animal Testing (CAAT) at the Johns Hopkins Bloomberg School of Public Health houses the first chair for EBT as well as the secretariat for the EBT Collaboration on both sides of the Atlantic. The EBT Collaboration was developed at the CAAT based on the Cochrane Collaboration in Evidence-based Medicine to support the creation of a process for quality assurance of new toxicity tests for the assessment of safety in humans and the environment.
In the last fifty years, regulatory safety sciences have changed surprisingly little. At the same time, our understanding of the life sciences doubles every seven years. Regulatory authorities such as the Environmental Protection Agency (EPA), the European Food Safety Authority (EFSA), and the United States National Toxicology Programme are beginning to adopt systematic reviews and associated evidence-based procedures. They give clear, objective, and consistent tools for identifying, selecting, evaluating, and extracting evidence across research.
This seminar will highlight these growing efforts and discuss potential and difficulties to expanding the use of these technologies in toxicology.
- Introduction & Shortcomings of Current Approaches
- History and Causation
- Systematic Review and Meta-Analysis
- Risk of Bias & Application to Test Methods Comparison
- Quality Assurance, Good Practices, and Validation
- Biometrical Tools & Future Perspectives