The course explains the subject and methods of Pathophysiology, as well as its place within the system of biomedical sciences and its history. It contains General Nosology (concept of health and disease, general aetiology and pathogenesis, pathological processes and states, role of causal factors, conditions, reactivity and somatotype in pathology). It provides a systematic review of typical pathological processes that are both locally and centrally driven: arterial, venous, and combined hyperemia, stasis, inflammation, immunopathological processes (including allergy and autoimmune disorders), acute phase response, fever, stress, shock, and so on. The course covers functional, metabolic, and informational aspects of common pathologic processes such as signalling, reception, post-receptor translation, programming and programme archiving, and programme conflicts in living systems. It includes an analysis of the resulting injury and defensive responses in individual cells, organs and tissues, and the entire organism. The lectures are based on the author's original three-volume textbook and workshop in Pathophysiology, which has been republished numerous times in Russia.
1. Pathophysiology as a Science
- "Pathophysiology as a Science"
- "Contribution of Various National Schools"
- "How and When Pathophysiology Separated From Anatomic Pathology"
- "Pathophysiology & Anatomic Pathology: Apart or Together?"
- "Pathophysiology as Systemic Pathobiology in Medical Knowledge"
- "Scientific Reasoning vs Clinical Reasoning"
- "Modeling of Diseases or Their Elements: Key Role in Medical Progress"
- "Spread of Pathophysiology Worldwide"
2. General Nosology. Health and Disease
- "Defense Can be Pathogenic and Costly"
- "Mosaic Character of Diseases. Elements of Disease"
- "General Aetiology & General Pathogenesis"
- "What is a Disease?"
- "Local and Systemic Mechanisms in Pathogenesis"
- "Specific and Non-Specific in Pathogenesis: is There Any Real Need in That Division?"
- "Health and Norm"
3. Aetiological doctrines: monocausalism, conditionalism and constitutionalism
- "Most Fruitful Doctrines in Medical Determinism"
- "Indirect Causality in Pathology: Examples"
- "Conditionalism – Principal Antipode of Monocausalism"
- "A Convergent Hybrid of Two Antipodes: Causalism"
- "Constitutionalism – a Medical Doctrine Put Reactivity in the Centre of System"
- "Multiple Classification but the Same Triple Division"
4. Locally driven typical pathological processes. Pathophysiology of microcirculation
- "What is Microcirculation?"
- "Regulation of Microcirculation Differs From That of Systemic Circulation"
- "Modelling of Microcirculatory Disorders: Experiment and Interpretation"
- "Arterial (Active) Hyperaemia"
- "Venous (Passive) Hyperaemia"
- "Combined (Mixed) Hyperaemia"
- "Stasis: Outcome of Typical Disorders of Microcirculation"
5. Pathophysiology of inflammation. Part 1
- "What is Inflammation?"
- "Components of Inflammation"
- "Models of Acute Inflammation"
- "Inflammation: Typical Pathological Under Predominant Local Regulation"
- "Barrier Function of Inflammation. Part 1"
- "Barrier Function of Inflammation. Part 2"
6. Pathophysiology of inflammation. Part 2
- "Acute Inflammation: Etiology and Onset"
- "Alternative Starters for Inflammation"
- "Mechanisms of Exudation. Part 1"
- "Mechanisms of Exudation. Part 2"
- "Role of Cell Adhesion Molecules (CAMs)"
- "Mediators of Inflammation: Groups and Effects. Part 1"
- "Mediators of Inflammation: Groups and Effects. Part 2"