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In this course, you will learn :
- Demonstrate understanding and application of the molecular principles underlying PCR/Sanger sequencing, Next Generation Sequencing, MLPA/MS MLPA, Southern blotting, array CGH, FISH, karyotyping, cell free foetal DNA extraction and analysis, and QF-PCR.
- Determine which laboratory investigation(s) are most appropriate for a given clinical scenario.
- Demonstrate a thorough understanding of at least four molecular genetic techniques' methodology.
Syllabus :
- Polymerase chain reaction (PCR)
- Sanger sequencing
- Southern blotting
- Multiplex ligation probe amplification (MLPA)
- Array comparative genomic hybridisation (array CGH)
- Karyotyping
- Fluorescent in situ hybridisation (FISH)
- Quantitative fluorescent PCR (QF-PCR)
- Single nucleotide polymorphism (SNP) genotyping and genome wide association studies (GWAS)
- The extraction and analysis of cell free fetal DNA, including non-invasive prenatal testing (NIPT).
